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Several genetic mutations in ASD have been associated with genes coding for proteins involved in synaptic functions, such as SH3 and multiple ankyrin repeat domains 3 (SHANK), contactin-associated protein-like (CNTNAP), neuroligin (NLGN), and neurexin (NRXN)

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The PLGA assembles without any functionalization have a high distribution up to 16.4% in the brain and can keep at the level for at least seven days

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